MACC1 and hepatocellular carcinoma: Mechanistically, MACC1 may contribute to cancer progression via the MACC1/hepatocyte growth factor (HGF)/c-Met axis (Boardman, 2009), as has been reported for ovarian cancer, gastric cancer, and HCC (Chang et al., 2012; Li et al., 2015; Dong et al., 2018).