There is a combination of (a) thrombocytopenia compensated with elevated levels of vWF, factor VIII and reduced ADAMTS-13, (b) a hypofibrinolytic state due to elevated PAI-1 and low plasminogen, and (c) elevated levels of pro-coagulant microparticles that may all lead to an increased risk of thrombosis and worsen outcome (23, 24). Here, VWF is linked to Thrombocytopenia.