Moreover, while the mean closure time of HS PDA was inversely proportional to GA (P53, P41, and P36 in EPTs with GA of 23–24, 25–26, and 27–28 weeks, respectively), a prolonged duration per week of HS PDA with a conservative non-intervention approach was not associated with increased mortality and/or morbidities in multivariate analyses adjusted for GA and birth weight (54). The gene discussed is TP53; the disease is Patent ductus arteriosus.