Two panels of three proteins each displayed a high discriminating ability; a panel of CRP, CETP, and apoA-IV for LOS vs. control (ROC AUC = 0.98) and a panel of apoA-VI, ApoC1, and LCAT for NEC vs. LOS at D0 (ROC AUC = 0.999). Here, LCAT is linked to necrotizing enterocolitis.