TLR4 and necrotizing enterocolitis: Experimental and/or clinical studies revealed several gene variants that were associated with increased risk of NEC, including, but not limited to, variants in the genes encoding nucleotide binding and oligomerization domain (NOD)-like receptors (NLRs), autophagy-related protein (ATG), angiotensinogen (AGT), IL8, KNG1- low-molecular-weight kininogen (LMWK) protein, ACACB- Acetyl-CoA Carboxylase Beta, and CAT- Catalase, and genes regulating the pathways of the receptors TLR2, TLR4, and TREM1 (47, 48, 125–128).