Statistical analyses revealed two panels of three proteins each having high discriminating ability; a panel of C-reactive protein, cholesteryl ester transfer protein (CETP), and apolipoprotein A-VI (apoA-IV) could differentiate between LOS at the onset of sepsis and controls (AUC = 0.98), while a panel of apolipoprotein A-VI, apolipoprotein C1, and lecithin-cholesterol acyltransferase discriminated NEC from LOS at the time of sepsis suspicion with excellent accuracy (AUC = 0.999 with 95% CI (0.987–1.00) (110). The gene discussed is APOA4; the disease is Sepsis.