<i>CTNNB1</i> gene mutation was firstly reported related to intellectual disability in 2012, to explore the clinical phenotype and genotype characteristics of <i>CTNNB1</i> mutation, we collected and analyzed the clinical data of a child with a neurodevelopmental disorder caused by a mutation of <i>CTNNB1</i>. Here, CTNNB1 is linked to neurodevelopmental disorder.