In females with CC, Th2-type cytokines (IL-10 and IL-13) induce the expression of arginase (ASE), which converts L-arginine into L-ornithine and polyamines, and a reduction in L-arginine is related to the downregulation of the immune response, further promoting tumor progression (Bedoya et al., 2014). The gene discussed is IL10; the disease is neoplasm.