Moreover, it was demonstrated that the Th17-associated cytokines, IL-17, IL-6, and IL-23, are crucial for granuloma formation during experimental paracoccidioidomycosis; thus, deficiency of IL-6, IL-23, or IL-17RA impaired the compact granuloma formation and conferred susceptibility to infection (Tristão et al., 2017). The gene discussed is IL17A; the disease is infection.