• Neutrophils are the predominant inflammatory cells located surrounding  mature spherules• Spherules and endospores are recognized via TLR-2 and Dectin-1• Source of IL-10• NETs and granuloma formation prevent fungal dissemination• Genetic patterns and pre-exposition influence phagocytic functionality• Presence of NOX2 limits neutrophil recruitment in coccidioidal infection. This evidence concerns the gene CLEC7A and coccidioidomycosis.