Interestingly, the adhesion ability of P. gingivalis W83 and KDP136 which is detected by flow cytometry are obviously lower than P. gingivalis 33277 (Supplementary Figure 4), but there is no significant difference between P. gingivalis 33277 and W83 in invasion detection, promoting the proliferation and activating MAPK/ERK signaling pathway of CRC cells (Figures 1B, C, Figure 2, Figure 5). The gene discussed is MAPK1; the disease is colorectal carcinoma.