The significant enriched pathways included prostate, lung, renal, colorectal, endometrial, thyroid cancers, glioma, and leukemia, the metabolism of amino acid, lipid and sugar, and some signal pathways of insulin, MAPK, TRL, VEGF, JAK-STAT, chemokine and p53, lysosome, peroxidome and ubiquitin-mediated protein degradation (P<0.05). The gene discussed is TP53; the disease is thyroid gland carcinoma.