The significant enriched pathways included prostate, lung, renal, colorectal, endometrial, thyroid cancers, glioma, and leukemia, the metabolism of amino acid, lipid and sugar, and some signal pathways of insulin, MAPK, TRL, VEGF, JAK-STAT, chemokine and p53, lysosome, peroxidome and ubiquitin-mediated protein degradation (P<0.05). Here, INS is linked to thyroid cancer.