BECN1 and breast carcinoma: In breast cancer cells, Beclin 1 overexpression improved cellular autophagy, inhibited cell proliferation, decreased cell apoptosis, mediated G1 arrest and promoted epithelial-mesenchymal transition (EMT) via Wnt/β- catenin pathway (40), but Becn1 knockdown induced EMT by via posttranscriptional up-regulation and stabilization of Zeb1 mRNA (41).