We observed p-p38 overexpression in Becn1-ovexpressing or silencing gastric cancer cells, but both p-PI3K and p-Akt hyperexpression was seen in Becn1-ovexpressing, but not Becn1-knockdown cells, suggesting that PI3K/Akt signal pathway might be involved in the effects of Beclin 1, but not p38. This evidence concerns the gene AKT1 and gastric cancer.