To assess this hypothesis, Panc02-bearing mice were injected with anti-PGPQLR IgGs, previously shown to a) neutralize the neuropilin-1 binding site of human CgA1-373 (PGPQLR373), b) cross-react with the corresponding site of its murine counterpart (100% conserved), and c) inhibit tumor growth in various murine models of solid tumors (8). This evidence concerns the gene NRP1 and neoplasm.