Of the second generation FLT3 inhibitors, an interim analysis of a phase I/II trial of quizartinib plus azacitidine in unfit patients with newly diagnosed or in R/R FLT3-ITD AML demonstrated an ORR of 75%, the secondary endpoint for the trial’s phase II portion, including in four/five patients with prior FLT3 inhibitor exposure (88). This evidence concerns the gene FLT3 and acute myeloid leukemia.