FLT3 and acute myeloid leukemia: To contrast, a randomized phase III trial of lestaurtinib plus frontline induction and consolidation chemotherapy in patients with FLT3-mutated AML demonstrated no difference in primary endpoints of OS (5-year OS 46% lestaurtinib vs 45% control, p = 0.3) or RFS (5-year RFS 40 vs 36%, p = 0.30) (45).