Mutations in Zinc finger homeobox 3 (ZFHX3), focal deletions in ETS Variant Transcription Factor 3 (ETV3), c-myc (MYC) amplifications in metastatic PCa, Histone-lysine N-methyltransferase 2D (KMT2D) truncations and Cyclin D1 (CCND1) amplifications in primary PCa were more frequent in tumors from AA patients. The gene discussed is ZFHX3; the disease is posterior cortical atrophy.