On the other hand, excessive gene expression of markers related to antitumor activity such as Interferon Gamma (INFG), Granzyme B (GZMB), and the immunotherapy targets Cytotoxic T-lymphocyte associated protein 4 (CTLA4) and Programmed death-ligand-1 (PDL1) proteins was observed in CA patients. The gene discussed is GZMB; the disease is cancer.