HTRA3 and neoplasm: As shown in Figures 4A–E and Table 1, overexpressed HTRA3 was significantly correlated with tumor histological type (mucinous type vs. tubular type, P = 0.003), histological grade (grade 3 vs. grade 1 and 2, P < 0.001), clinical stage (stage IV vs. stage I, P < 0.001), T stage (T4 vs. T1, P < 0.001), and TP53 status (wild type vs. mutational type, P = 0.014).