HAVCR2 and hepatocellular carcinoma: Also, it was reported that tumor-infiltrated conventional NK (cNK) and liver resident NK (LrNK) cells showed elevated TIM-3 expression in HCC patients (Figure 2), which, in turn, suppresses their cytokine secretion and cytotoxicity because TIM-3 disrupts the downstream Akt/mTORC1 signaling in NK cells (66).