In this study, hypoexpression of cdc25B and cdc25c was associated with the suppressing effects of Dkk3 on proliferation and tumor growth as cdc25B activates Cyclin-dependent kinase CDC2 required for mitosis progression; concurrently, cdc25C promotes Cyclin B-Cdk1 complex formation required for G2/M phase transition (38). Here, DKK3 is linked to neoplasm.