Slug and twist promoted epithelial-mesenchymal transition (EMT) alongside E-cadherin under-expression and N-cadherin hyperexpression (40); downregulated expression of N-cadherin and of slug and twist, and upregulation of E-cadherin might result in the inhibitory effects of Dkk3 in EMT of colorectal cancer cells. The gene discussed is DKK3; the disease is colorectal cancer.