Herein, the Dkk3 mRNA expression level was higher in nested than in filtrated cancer tissue, and recombinant Dkk3 and ectopic Dkk3 expression seemed to attenuate the migrative and invasive capacities of colorectal cancer cells, indicating that both kinds of intervention might effectively inhibit the risk of invasion or metastasis in advanced colorectal cancer. The gene discussed is DKK3; the disease is colorectal cancer.