In this study, hypoexpression of cdc25B and cdc25c was associated with the suppressing effects of Dkk3 on proliferation and tumor growth as cdc25B activates Cyclin-dependent kinase CDC2 required for mitosis progression; concurrently, cdc25C promotes Cyclin B-Cdk1 complex formation required for G2/M phase transition (38). This evidence concerns the gene CDK1 and neoplasm.