To assess the potential contribution of high expression of IDO1 with high expression of CD8A in tumor development, all mice given intrasplenic injection of SL4 cells were divided into four groups according to the median value in IDO1 or CD8A levels as follows: CD8AlowIDO1low, CD8AlowIDO1high, CD8AhighIDO1low, and CD8AhighIDO1high (Figure 9C). This evidence concerns the gene IDO1 and neoplasm.