Although leukemia does not necessarily undergo EMT, E-cadherin expression is reduced by hypermethylation of the E-cadherin gene promoter (90, 91), while VE-cadherin and N-cadherin expression contributes to chemoresistance in BCR-ABL+ (Ph+) ALL and CML (92, 93). This evidence concerns the gene CDH5 and acute lymphoblastic leukemia.