Mesenchymal stromal cell (MSC)-N-cadherin adhesion in CML LSC also provides tyrosine kinase imatinib resistance by stabilizing N-cadherin/β-catenin complex formation and the nuclear translocation of β-catenin in concert with the activation of exogenous Wnt/β-catenin signaling (92). Here, CDH2 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.