VE-cadherin expression along with PECAM-1 expression on ALL enhances the adhesion of leukemia cells to human brain-derived microvasculature endothelial cells (HBMECs) and their migration through the HBMEC monolayer, suggesting a role of VE-cadherin in the central nervous system (CNS) infiltrating leukemia (94). This evidence concerns the gene CDH5 and acute lymphoblastic leukemia.