TNF and neoplasm: It is known that in the circulating immune system, lymphocytes kill tumor cells and inhibit distant metastasis, and a large increase in neutrophils can secrete cytokines interleukin (IL)-1, IL-10, interferon-γ and tumor necrosis factor-α and other factors to inhibit lymphocytes (CD4+ and CD8+ cells) and natural killer cells, promote tumor immune escape, and enhance tumor cell resistance.