IDH1 and central nervous system cancer: Even though most commonly used to describe GBMs, the VASARI features have also been applied to lower grade gliomas (LGG): Hyare et al. tried to predict isocitrate dehydrogenase 1 (IDH1) mutation status (26), Zhou et al. aimed at predicting histological grade and tumor progression as well as mutation status (IDH1 and 1p/19q codeletion) (27) and Lehrer et al. evaluated the relationship between MR tumor characteristics and protein measurements (28).