Mutations in BRCA1/2 are considered as risk factors for the onset of breast cancer (131); Atchley et al. reported a significant association between mutations in breast cancer susceptibility gene 1 (BRCA1) and TNBC, with more than 2/3 of BRCA1 mutations cases being of TNBC phenotype (132). This evidence concerns the gene BRCA1 and breast carcinoma.