Earlier studies evaluated tumor histology as well as the prognostic and predictive markers (ER, PR, HER‐2/neu, p53, and Ki‐67) in PABC; in comparison to age-matched non-pregnant women, their findings show that PABC exhibit lower expression of ER/PR and higher expression Ki‐67, p53 HER2 (23, 25, 26, 43, 51–53). This evidence concerns the gene ESR1 and neoplasm.