Specifically, MDM2 was found to upregulate MYCN RNA levels and MYCN translation in NB1691 and SK-N-SH neuroblastoma cells and in RB176 and Y79 retinoblastoma cells, effects attributed to MYCN RNA stabilization and ribosomal loading in the neuroblastoma setting (15, 17). The gene discussed is MDM2; the disease is retinoblastoma.