Specifically, MDM2 was found to upregulate MYCN RNA levels and MYCN translation in NB1691 and SK-N-SH neuroblastoma cells and in RB176 and Y79 retinoblastoma cells, effects attributed to MYCN RNA stabilization and ribosomal loading in the neuroblastoma setting (15, 17). This evidence concerns the gene MDM2 and neuroblastoma.