KLRC1 and neoplasm: The interaction between NKG2A and HLA-E is thought to block the cytotoxic activity of CD8+ T cells and NK cells (100) and a couple of studies have shown that expression of HLA-E by tumor cells restrained the prognostic impact of tumor-infiltrating CD8+ T cells (98, 99), including that of HPV16+ OPSCC (97).