IRF4 and Autoimmunity: In mice, Foxp3+ Tregs have been described to upregulate signal transducer and activator of transcription 3 (STAT3), GATA binding protein 3 (GATA-3)/interferon regulatory factor 4 (IRF4), or Tbet to control T helper type 17 (Th17), Th2 or Th1 inflammatory responses, respectively, in persistent infection and autoimmunity (63–66).