This assertion is based on several observations: (1) CircMEG3 is downregulated expression and negatively correlated with the expression of telomerase-related gene Cbf5 in human liver cancer; and (2) CircMEG3 inhibits the growth ability of human liver CSCs in vitro and in vivo. A MEG3 acts as an antitumor component in different cancer cells, such as breast and liver cancer cells.39 This evidence concerns the gene MEG3 and cancer.