METTL3 and cancer: Given the multiple functions of METTL3 in human cancers, we considered investigating whether CircMEG3 inhibits the expression of Cbf5, a component of human liver CSC telomere synthase H/ACA RNP (catalytic RNA pseudourea modification); dependent on METTL3, the methylation modification of Cbf5 mRNA was detected in the DOX groups (0, 0.5, 1, 1.5, and 2 μg/mL) of rLV-Tet-on-CircMEG3-hLCSCs.