TSC2 and Epileptic spasm: She was diagnosed with TSC with psychotic symptoms.<h4>Discussion</h4>TSC2 mutations usually present early with epileptic spasms (ES), complex epilepsies, intellectual and cognitive deficits, cardiac rhabdomyomas, and sub-ependymal giant-cell astrocytomas (SEGAs) with high tuber-to-brain proportions (TBP).