Moreover, several studies also revealed that Ang II could increase cerebral hypoperfusion-induced anxiety-like behavior and promote memory impairment [41], induce neuronal dysfunction [42], contribute to the pathogenesis of Alzheimer's Disease [43], cause neuronal damage [44] hippocampal neural stem cell death, and memory impairment [45]. The gene discussed is AGT; the disease is early-onset autosomal dominant Alzheimer disease.