HAMP and hyperinsulinemic hypoglycemia, familial, 4: Notably, in addition to AUR which acts as a ferroptosis inducer by TXNRD inhibition in high-dose situation, low-dose AUR can relieve iron overload by increasing hepcidin expression via the NF-κB/IL-6/JAK-STAT pathway [45], which indicated that despite the new indication for proferroptotic anticancer therapy, AUR could also be repurposed to treat other hepcidin deficiency diseases.