In this study, we constructed lentiviral vectors containing NLRC3 through intracerebroventricular injection in 12-month-old APPswe/PS1-dE9 (amyloid precursor protein/presenilin protein 1 (APP/PS1)) double transgenic model mice which represents mid-term of AD when animals develop Aβ formation, show pathological changes in brain tissue and structure, and exhibit learning and memory function obstacles. Here, NLRC3 is linked to Alzheimer disease.