To mimic the effects of E22K or Aβ on blood catalase activity and H2O2 levels in early-onset or late-onset AD patients, we incubated the blood from healthy controls with the synthetic E22K (a proposed inhibitor of catalase in this study) and Aβ (a confirmed inhibitor of catalase) [24], respectively (Figure S1). Here, CAT is linked to Alzheimer disease.