NFE2L2 and COVID-19: ,25, 26, 27, 28, 29, 30, 31 It has been proposed but not confirmed that Nrf2-interacting nutrients may be effective in COVID 19.32, 33, 34, 35, 36 The cases presented herein are a proof-of-concept for the clinical effects of Nrf2-interacting nutrients in patients with COVID-19 using broccoli and glucoraphanin.