Carriers of at least one polymorphic CAT rs1001179 allele were still significantly more likely to be NYHA class 2 (OR = 5.09, 95% CI = 1.08-24.02, P = 0.040) in univariable analysis, while only a trend was observed after adjustment for hyperlipidemia and BMI (OR = 5.94, 95% CI = 0.84-42.22, P = 0.075). This evidence concerns the gene CAT and hyperlipidemia.