High expression of NQO1 can inhibit 26S proteasome degradation mediated by ubiquitin to enhance the stability of SIRT6 protein, lead to the increase of AKT phosphorylation and activity, further affect the stability of antiapoptotic protein XIAP, and enhance the apoptotic escape of hepatocellular carcinoma cells [19]. The gene discussed is NQO1; the disease is hepatocellular carcinoma.