By comparing tumor tissues and normal tissues, it was found that there are differences in the expression of multiple lncRNAs in HCC (Lanzafame et al., 2018), and some lncRNAs can regulate ARGs at the transcriptional and post-transcriptional levels, thereby participating in the autophagy pathway (Yang et al., 2016; Jing et al., 2020). This evidence concerns the gene SERPINA2 and hepatocellular carcinoma.