Baulies et al. (2018) suggested that the overexpression of SLC25A11 works as an adaptive mechanism of HCC to provide enough GSH for abundant cell growth, while SLC25A11 induces the export of AKG to the cytosol to activate the mTOR pathway to promote cell growth and anabolism through egl-9 family hypoxia-inducible factors (EGLNs) (Villar et al., 2015). The gene discussed is MTOR; the disease is hepatocellular carcinoma.