Here, we have employed an integrative bioinformatics approach to investigate the transcriptomic changes in the mouse lung tissue underlying the deletions of Cd151 and Cd9 to (a) gain a perspective of a corresponding phenomenon in context of the human lung and; (b) to better understand the preventive roles of Cd151 and Cd9 in pulmonary fibrosis and emphysema, respectively (Figure 1A). This evidence concerns the gene CD151 and pulmonary fibrosis.