FAS and small cell lung carcinoma: In Cd9KO-network, FAS, of the TNF-receptor superfamily that functions in extrinsic apoptosis pathway, was tagged as a bottleneck-hub (Supplementary Table S7), while MAPK10, a pro-apoptotic factor, known to be deleted in small-cell-lung-cancer (Kim et al., 2006), was identified as a bottleneck (Supplementary Table S7).