In particular, ELK3, ETS1, ETV1, ETV4, ETV5, and SPI1 were significantly upregulated in melanoma (Figures 2A–F), whereas EHF, ELF3, ELF5, ERG, ETS2, ETV7, and SPDEF were significantly downregulated in the tumor (Figures 2G–M). The gene discussed is SPI1; the disease is melanoma.