SPDEF and neoplasm: In particular, ELK3, ETS1, ETV1, ETV4, ETV5, and SPI1 were significantly upregulated in melanoma (Figures 2A–F), whereas EHF, ELF3, ELF5, ERG, ETS2, ETV7, and SPDEF were significantly downregulated in the tumor (Figures 2G–M).