In this systematic analysis of the ETS family in melanoma, we first integrated the data from the TCGA and GTEx databases and three available cohorts of melanoma patients in the Oncomine database; we then found that ELK3, ETS1, ETV1, and ETV5 were significantly upregulated in melanoma, whereas ELF3, ELF5, ETS2, ETV7, and SPDEF were significantly downregulated in the tumor. Here, SPDEF is linked to melanoma.