Given that both polymorphisms in the IgG3 heavy chain gene and FcgR can influence the IgG binding on immunoglobulin Fc-receptors and impact immunity to malaria through ADCC, ADCI, or phagocytosis of malaria parasites, the interpretation of results coming from separate investigations of these distinct polymorphisms remains challenging. The gene discussed is IGHG3; the disease is malaria.