CD8A and allergic disease: This also affects the CD8 compartment, resulting in CD8+ T cells with a more type-2 phenotype (Tc2), which can exacerbate allergy-type reactions in asthma or infection with respiratory syncytial virus (RSV) (106–109).Thus, the immune response generated by neonatal T cells is more of an innate nature, whereas adults produce cytokines that are typically associated with adaptive immune responses.