IGFBP4 and cancer: On the other side, greatest decreases were observed for genes like Nrep (-4.1-fold), playing a role in the regulation of transforming growth factor beta receptor signaling pathway, Evl (-1.8-fold), a highly expressed gene in white blood cells, as well as its corresponding protein, a member of the Ena/VASP family, Igfbp4 (-2.5-fold), known to act as an apoptotic factor by reducing the growth of several cancers (17), or Bcl2l11 (-2.3-fold), coding for the BIM apoptotic activator, whose deficiency results in Treg enhanced survival and accumulation (18).