Also, the inter-generational (parental) effect of BBP on allergic asthma has been observed (17), in which maternal BBP exposure was shown to promote airway inflammation over 2 generations and hypermethylation of the gene encoding GATA-3 repressor zinc finger protein 1 (Zfpm1) was suggested as a candidate associated with Th2-driven allergic asthma in murine F1 neonatal splenic CD4+ T cells; however, the possibility that it is due to the effect of maternal BBP on F1 fetus and F2 germline cannot be ruled out (18, 31) and the functional consequences in allergic responses are unclear. The gene discussed is CD4; the disease is allergic asthma.