CD274 and cervical carcinoma: In a previously published study on cervical cancer though, we have had good experience with this clone for the detection of PD-L1 on both tumor cells as well as on immune cells (24), and as well, the SP142 clone has been approved by the FDA as companion diagnostic for atezolizumab (anti-PD-L1) treatment in several other cancer indications (52, 53).