We evaluated the expression of CXCL10, TNF-α, CCL2, CCL3, IL-8, and IL-6 among 74 volunteers, from a pool of 923, with one (HbAS and HbAC), two (HbSS, HbSC, HbCC) and no (HbAA) copies of the Hb allele variant S and/or C with (+) and without (-) malaria. This evidence concerns the gene TNF and malaria.