The latter feature, in particular, is suggestive of shared aetiology with Cryopyrin (NLRP3)–associated periodic syndrome (CAPS or NLRP3-AID), which is an inherited or, in rare circumstances, an acquired disorder associated with gain of function mutations in NLRP3 leading to uncontrolled release of IL-1. The gene discussed is NLRP3; the disease is cryopyrin-associated periodic syndrome.