Recent studies have found that the down-regulation of ERLIN2 gene increases cell apoptosis and inhibits the proliferation, invasion and migration of breast cancer cells, which may be related to PI3K/AKT signaling pathway (20).To evaluate the carcinogenic effect of ERLIN2 in LUAD, we knocked down ERLIN2 in A549 and H1299 cells. This evidence concerns the gene AKT1 and breast cancer.