Unsurprisingly, we found that this ratio was higher in AHA-only controls (an oligoclonal setting in which only anti-FVIII IgG4+ plasma cells proliferate) than in IgG4-RD-only controls (a polyclonal setting in which all IgG4+ plasma cells proliferate equally) (Figure 4). The gene discussed is F8; the disease is autoimmune hemolytic anemia.