In fact, in hyperinsulinemic euglycemic clamp studies with an insulin infusion rate of 1.0 mU/kg/min, there is a significant 30% increase in basal endogenous glucose production at 34 to 36 weeks’ gestation in comparison with 12–14 weeks’ gestation measurements in women with either normal glucose tolerance or GDM, without differences between the groups (49, 50). The gene discussed is INS; the disease is gestational diabetes.