SREBF1 and metabolic disease: Moreover, adult male offspring from HFD mothers are predisposed to fat accumulation, with an increased visceral, gonadal and perirenal fat depots, and with hyperleptinemia: the adipose tissue depots exhibits elevated sterol regulatory element-binding protein 1 (SREBP1), fatty acid synthase (FAS), leptin, and diminished PPARγ mRNA levels (157), establishing the basis for metabolic diseases in adulthood.