Early glucagon excursion (glucagon levels at 15 min time point of the MMTT) was associated with the risk of later hypoglycemia (binary logistic regression: p=0.045) and correlated positively with glycemic nadir, even after suppressing postprandial hyperinsulinemia effect (partial correlation: r=0.628, p=0.002). This evidence concerns the gene GCG and Hyperinsulinemia.