Based on information from OMIM, all patients, except patient #7, presented at least one variant in a gene with autosomal dominant (AD) inheritance (GLI2, FLNA, GLI3, NOTCH2, PTPN11, and RET); the other genes (CDH23 and MYO7A) exhibited either AD or autosomal recessive (AR) inheritance. The gene discussed is PTPN11; the disease is Alzheimer disease.