KCNJ10 and cerebellar ataxia: In addition, studies using conditional knockout techniques have reported that mice with conditional knockout of astrocytic Kir4.1 developed pronounced body tremor, ataxia, and stress-induced GTCSs, which were suggested to be involved in astrocytic membrane depolarization and impaired uptake of extracellular K+ following neural activity (Table 1) (30, 85, 86).