It has been proposed that tPA, which works immediately on clot breakdown, may facilitate the use of MT and help to treat distal embolization (7, 8); however, a recent study published in Stroke suggested that the use of IV tPA prior to mechanical lysis may complicate the procedure by converting easy to reach clots located at the proximal M1 branch to distal M2 branches (9). This evidence concerns the gene PLAT and stroke disorder.