Transgenic mouse models of AD, including the htau, amyloid precursor protein (APP)/presenilin1 mutant, and Swedish mutation APP strains exhibit low BMD (Cui et al., 2011; Yang et al., 2011; Xia et al., 2013; Peng et al., 2014; Dengler-Crish et al., 2016). Here, APP is linked to Alzheimer disease.